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(Post-COVID conditions)

Some people, especially those who had severe COVID-19, experienced multi-organ effects or autoimmune conditions with symptoms lasting weeks or months after having COVID-19.

Multiorgan effects can involve many body systems, including the heart, lung, kidney, skin and brain. As a result of these effects, people who have had COVID-19 may be more likely to develop new health conditions such as diabetes, heart conditions, or neurological conditions compared with people who have not had COVID-19.


COVID-19 Specific Nutraceutical & Botanical Agents

The following compounds are recommended at standard dosages to prevent activation of the NLRP3 inflammasome, to decrease NF-kB activation, and to potentially inhibit SARS-CoV-2 replication. 


  • Discussion: 

  • Dose: 30-60 mg daily, in divided doses

  • Outcomes: reduced severity of symptoms; reduced duration of illness


  • Discussion: Elderberry has widespread historical use as an anti-viral herb that is effective for prevention and treatment of early infection with some respiratory viruses.

  • Dose: 500 mg daily for up to 12 weeks

  • Outcomes: reduction and improvement in symptoms; reduced incidence and duration

Vitamin D

  • Discussion: Activated Vitamin D is a steroid hormone that is an immune system modulator which reduces the expression of inflammatory cytokines and increases macrophage function. 

  • Dose: 5,000 IU daily (in the absence of serum levels)

  • Outcomes: Reduce progression from colonization to illness

Vitamin A

  • Discussion: Vitamin A is involved in the development of the immune system and plays regulatory roles in the cellular and humoral immune response. 

  • Dose: Up to 10,000 - 25,000 IU daily

  • Outcomes: Reduction in symptom duration; reduction of illnesses associated with viral strains; mortality reduction

Vitamin C

  • Discussion: Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. 

  • Dose: 1-3 grams daily

  • Outcomes: Reduced mortality with sepsis


  • Discussion: Quercetin has been shown to have antiviral effects against both RNA (e.g. influenza and coronavirus) and DNA viruses (e.g. herpesvirus). 

  • Dose: 

    • Regular: 1 gm twice a day for up to 12 weeks​

    • Phytosome: 500 mg twice a day for up to 12 weeks

  • Outcome: Reduction of symptoms​

Epigallocatechin Gallate (Green tea)

  • Discussion: Green tea modulates the NLRP3 inflammasome and has been shown to prevent influenza in healthcare workers

  • Dose: 4 cups daily or 225 mg daily


  • Discussion: Curcumin has been shown to modulate the NLRP3 inflammasome

  • Dose: 500-1,000 mg twice a day


  • Discussion: Melatonin has been shown to have an inhibitory effect on the NLRP3 inflammasome. 

  • Dose: 5-20 mg daily


  • Discussion: Resveratrol has been shown to modulate the NLRP3 inflammasome.

  • Dose: 100-150 mg daily

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